ANP32E

Across TCGA pan-cancer cohorts, ANP32E RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ANP32E’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ANP32E RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ANP32E is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

HNSC, BLCA, and LUAD are the cancer types where ANP32E tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANP32E RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.367	<.001	12	view →
BLCA	Female	All	+0.938	<.001	10	view →
LUAD	Male	II,III,IV	+1.278	<.001	9	view →
LIHC	Male	II,III,IV	+1.203	<.001	9	view →
KICH	Female	II,III,IV	−2.238	<.001	8	view →
STAD	Male	II,III,IV	+1.282	<.001	8	view →
LUSC	All	All	+0.943	<.001	8	view →
BRCA	All	II,III,IV	+0.700	<.001	6	view →
CHOL	Male	All	+2.338	<.001	5	view →
UCEC	All	All	+0.863	<.001	4	view →
COAD	Male	II,III,IV	+0.601	.002	4	view →
ESCA	All	All	+1.321	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ANP32E–HNSC

Open the HNSC breakdown →