ANP32AP1

Across TCGA pan-cancer cohorts, ANP32AP1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ANP32AP1 data layer compared with 7 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ANP32AP1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ANP32AP1 expression acts as an unfavorable survival marker, although some lineages such as CHOL and LUAD show a favorable association.

ACC, LUSC, and CHOL are the cancer types where ANP32AP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	II,III,IV	0.222	0.835	<.001	48	view →
LUSC	OS	Median	III,IV	0.552	0.820	<.001	33	view →
CHOL	OS	Median	All	0.960	0.564	.004	31	view →
LGG	DFS	Quartile	All	0.767	0.871	.005	27	view →
KIRC	DFS	Median	All	0.769	0.833	.008	22	view →
LUAD	DFS	Tertile	IV	0.693	0.220	.014	22	view →
STAD	OS	Quartile	III,IV	0.336	0.650	.009	22	view →
SKCM	OS	Median	II,III,IV	0.671	0.805	.005	20	view →
ESCA	OS	Median	III,IV	0.571	0.301	.001	19	view →
PAAD	DFS	Tertile	All	0.357	0.625	.002	17	view →
UVM	DFS	Median	III,IV	0.401	0.677	.016	14	view →
OV	OS	Tertile	II,III,IV	0.785	0.868	.029	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ANP32AP1–ACC (DFS)

Open the ACC breakdown →