ANO8

Across TCGA cell cohorts, ANO8 mutation is significantly associated with the RNA expression of many other genes, with 753 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ANO8-associated genes across cancer lineages are TRMU, PCSK4, and TTI2. Each is linked with ANO8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANO8-to-partner and partner-to-ANO8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRMU grouped by ANO8-low versus ANO8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANO8→partner) and Y-score (partner→ANO8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TRMU →	+0.588	+3.259	.001	.006	3	2
BLOOD_Leukemia	PCSK4 →	+1.133	+3.199	.001	.007	3	2
BLOOD_Leukemia	TTI2 →	+0.558	+3.199	<.001	.007	3	2
BLOOD_Leukemia	FAM98C →	+0.643	+3.199	.005	.007	3	2
BLOOD_Leukemia	ZIC5 →	+0.631	+2.889	<.001	.003	3	2
BLOOD_Leukemia	LYG1 →	+0.684	+3.318	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 753 associations by consensus.

TRMU by ANO8 expression — BLOOD_Leukemia

Explore this box plot interactively →