ANO6

Across TCGA pan-cancer cohorts, ANO6 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ANO6’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ANO6 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ANO6 is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

LUAD, CCRCC, and COAD are the cancer types where ANO6 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANO6 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	−0.606	<.001	9	view →
CCRCC	Male	III,IV	+0.346	<.001	9	view →
COAD	Female	All	−0.297	<.001	9	view →
LSCC	Female	All	−0.558	<.001	8	view →
HNSC	All	IV	+0.330	<.001	8	view →
PDAC	Female	All	−0.621	<.001	6	view →
OV	All	All	−0.601	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ANO6–LUAD

Open the LUAD breakdown →