ANO6

Across TCGA patient cohorts, ANO6 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANO6-associated genes across cancer lineages are JNK2, p62 Lck ligand, and Rad50. Each is linked with ANO6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANO6-to-partner and partner-to-ANO6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by ANO6-low versus ANO6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANO6→partner) and Y-score (partner→ANO6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.214	+3.611	.001	.001	3	2
UCEC	p62 Lck ligand →	+0.406	+2.523	<.001	<.001	3	2
UCEC	Rad50 →	-0.179	-1.247	.030	.045	3	2
UCEC	ASNS →	+0.439	+1.514	<.001	.015	3	2
UCEC	ATM →	-0.620	-2.523	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.400	+2.523	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

JNK2 by ANO6 expression — UCEC

Explore this box plot interactively →