ANO4

Across TCGA patient cohorts, ANO4 mutation is significantly associated with the total protein of many other genes, with 87 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANO4-associated genes across cancer lineages are GAPDH, Caspase-7-cleavedD198, and eEF2. Each is linked with ANO4 in more than 4 cancer types. Because this analysis shows association rather than direction, both ANO4-to-partner and partner-to-ANO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ANO4-low versus ANO4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANO4→partner) and Y-score (partner→ANO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GAPDH →	+0.635	+3.169	.005	.018	3	5
LUAD	Caspase-7-cleavedD198 →	+0.527	+2.717	.005	.003	2	5
UCEC	eEF2 →	+0.237	+1.999	.017	.008	3	3
LUAD	FOXO3a_pS318_S321 →	-0.130	-2.700	.004	.006	3	3
LUAD	ACC1 →	+0.415	+2.186	.013	.032	3	3
LUSC	p27 →	-0.142	-3.000	.022	.033	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 87 associations by consensus.

GAPDH by ANO4 expression — LUAD

Explore this box plot interactively →