ANO4

Across TCGA pan-cancer cohorts, ANO4 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ANO4 data layer compared with 10 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher ANO4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ANO4 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

UVM, KIRC, and STAD are the cancer types where ANO4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.290	0.737	<.001	147	view →
KIRC	OS	Median	All	0.695	0.564	<.001	96	view →
STAD	OS	Tertile	II,III,IV	0.556	0.843	.001	69	view →
UCS	DFS	Tertile	III,IV	0.548	0.085	.001	54	view →
UCEC	DFS	Tertile	IV	0.950	0.631	.009	36	view →
LUSC	OS	Tertile	III,IV	0.265	0.602	.007	32	view →
KIRP	DFS	Median	IV	0.039	0.623	.001	30	view →
THCA	OS	Quartile	II,III,IV	0.951	1.000	.006	23	view →
CESC	OS	Quartile	II,III,IV	0.839	0.584	.010	22	view →
MESO	OS	Quartile	II,III,IV	0.466	0.704	.018	20	view →
SKCM	OS	Median	II,III,IV	0.470	0.142	<.001	18	view →
ACC	OS	Tertile	All	0.495	0.853	.012	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ANO4–UVM (DFS)

Open the UVM breakdown →