ANO4

Across TCGA cell cohorts, ANO4 mutation is significantly associated with the RNA expression of many other genes, with 222 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANO4-associated genes across cancer lineages are C12orf42, TAS1R2, and ZNF418. Each is linked with ANO4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANO4-to-partner and partner-to-ANO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C12orf42 grouped by ANO4-low versus ANO4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANO4→partner) and Y-score (partner→ANO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C12orf42 →	+0.200	+4.222	<.001	.007	3	2
BLOOD_Leukemia	TAS1R2 →	+0.011	+3.855	<.001	.007	3	2
LUNG_SCLC	ZNF418 →	-1.378	-3.009	.004	.008	3	2
CNS	SPATS1 →	+0.233	+3.115	.001	.001	3	2
LARGE_INTESTINE	ZNF330 →	+0.456	+3.364	.009	.002	3	2
LUNG_NSCLC_LUAD	POTEH →	+0.510	+2.273	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 222 associations by consensus.

C12orf42 by ANO4 expression — SOFT_TISSUE

Explore this box plot interactively →