ANO4

Across TCGA cell cohorts, ANO4 mutation is significantly associated with the mutation status of many other genes, with 4,632 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANO4-associated genes across cancer lineages are LAMA1, HMCN1, and NBEA. Each is linked with ANO4 in more than 5 cancer types. Because this analysis shows association rather than direction, both ANO4-to-partner and partner-to-ANO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LAMA1 grouped by ANO4-low versus ANO4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANO4→partner) and Y-score (partner→ANO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LAMA1 →	+4.307	+4.307	.001	.001	1	6
LARGE_INTESTINE	HMCN1 →	+1.251	+2.725	.003	.003	1	6
OESOPHAGUS	NBEA →	+2.830	+3.146	.006	.006	1	5
LUNG_NSCLC_LUAD	BRINP2 →	+3.228	+3.078	<.001	<.001	1	5
UPPER_AERODIGESTIVE_TRACT	WDR17 →	+4.023	+5.075	<.001	<.001	1	5
OVARY	NDST4 →	+4.977	+4.415	.007	.007	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,632 associations by consensus.

LAMA1 by ANO4 expression — SOFT_TISSUE

Explore this box plot interactively →