ANLN

Across TCGA cell cohorts, ANLN mutation is significantly associated with the RNA expression of many other genes, with 183 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANLN-associated genes across cancer lineages are CARD18, MSMB, and H4C6. Each is linked with ANLN in more than 1 cancer types. Because this analysis shows association rather than direction, both ANLN-to-partner and partner-to-ANLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CARD18 grouped by ANLN-low versus ANLN-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANLN→partner) and Y-score (partner→ANLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CARD18 →	+0.323	+4.369	<.001	<.001	3	2
SOFT_TISSUE	MSMB →	+0.130	+3.295	<.001	.006	3	2
LUNG_NSCLC_LUAD	H4C6 →	+0.226	+4.212	.002	.007	3	2
BLOOD_Lymphoma	OR56A1 →	+0.035	+2.938	<.001	.004	3	2
BLOOD_Lymphoma	ZNF728 →	+0.569	+3.130	<.001	.006	3	2
BLOOD_Myeloma	ESX1 →	+0.126	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 183 associations by consensus.

CARD18 by ANLN expression — SOFT_TISSUE

Explore this box plot interactively →