ANKS6

Across TCGA cell cohorts, ANKS6 mutation is significantly associated with the RNA expression of many other genes, with 777 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANKS6-associated genes across cancer lineages are HELT, HPS4, and DEPDC5. Each is linked with ANKS6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKS6-to-partner and partner-to-ANKS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HELT grouped by ANKS6-low versus ANKS6-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKS6→partner) and Y-score (partner→ANKS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HELT →	+0.027	+4.321	<.001	.009	3	1
LARGE_INTESTINE	HPS4 →	+0.512	+3.169	.006	.009	3	1
LARGE_INTESTINE	DEPDC5 →	+0.644	+2.628	<.001	.002	3	1
LARGE_INTESTINE	CBY1 →	+0.690	+3.482	<.001	<.001	3	1
LARGE_INTESTINE	JOSD1 →	+0.619	+3.459	<.001	.001	3	1
LARGE_INTESTINE	MIOX →	+0.343	+3.409	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 777 associations by consensus.

HELT by ANKS6 expression — CNS

Explore this box plot interactively →