ANKS6

Across TCGA pan-cancer cohorts, ANKS6 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ANKS6’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ANKS6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ANKS6 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

COAD, STAD, and KICH are the cancer types where ANKS6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANKS6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+1.542	<.001	11	view →
STAD	Male	II,III,IV	+1.274	<.001	10	view →
KICH	Male	All	−1.693	<.001	8	view →
LIHC	Female	II,III,IV	+1.506	<.001	8	view →
HNSC	Male	All	+0.833	<.001	8	view →
BRCA	All	III,IV	−0.855	<.001	6	view →
KIRC	Male	II,III,IV	−0.475	<.001	6	view →
THCA	Male	All	+0.408	<.001	6	view →
CHOL	Male	All	+2.711	<.001	5	view →
READ	All	All	+1.194	<.001	3	view →
PRAD	All	All	+0.555	<.001	2	view →
ESCA	All	All	+0.821	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ANKS6–COAD

Open the COAD breakdown →