ANKS4B

Across TCGA pan-cancer cohorts, ANKS4B mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of ANKS4B’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where ANKS4B mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ANKS4B is over-expressed in tumor, although a few such as CCRCC and COAD show the opposite, repressed pattern.

CCRCC, COAD, and PDAC are the cancer types where ANKS4B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANKS4B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	II,III,IV	−1.411	<.001	12	view →
COAD	Female	III,IV	−0.350	<.001	11	view →
PDAC	All	All	+0.535	.043	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

ANKS4B–CCRCC

Open the CCRCC breakdown →