ANKS4B

Across TCGA pan-cancer cohorts, ANKS4B RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ANKS4B data layer compared with 3 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ANKS4B RNA is associated with better overall survival. In most high-consensus cancer types, elevated ANKS4B expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

KIRC, READ, and KICH are the cancer types where ANKS4B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.720	0.529	<.001	189	view →
READ	DFS	Median	All	0.742	0.269	.001	63	view →
KICH	OS	Median	III,IV	0.468	1.000	.001	57	view →
CESC	DFS	Quartile	IV	0.128	0.560	.003	48	view →
KIRP	OS	Median	III,IV	0.757	0.201	.010	36	view →
ACC	OS	Median	IV	0.974	0.479	.002	32	view →
SCLC	OS	Quartile	All	0.635	0.324	.005	28	view →
UVM	OS	Quartile	All	0.412	0.862	.023	21	view →
GBM	OS	Tertile	All	0.306	0.520	<.001	21	view →
MESO	OS	Tertile	IV	0.077	0.647	.004	18	view →
ESCA	OS	Median	All	0.617	1.000	.009	18	view →
SKCM	DFS	Tertile	All	0.148	0.217	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ANKS4B–KIRC (OS)

Open the KIRC breakdown →