ANKS4B

Across TCGA patient cohorts, ANKS4B mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKS4B-associated genes across cancer lineages are MEK1, FoxM1, and 14-3-3_beta. Each is linked with ANKS4B in more than 2 cancer types. Because this analysis shows association rather than direction, both ANKS4B-to-partner and partner-to-ANKS4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ANKS4B-low versus ANKS4B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKS4B→partner) and Y-score (partner→ANKS4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.382	+2.321	.007	.005	3	3
UCEC	FoxM1 →	+0.270	+2.000	.007	.010	3	2
UCEC	14-3-3_beta →	-0.106	-1.986	.007	.010	3	1
UCEC	EGFR_pY1068 →	-0.329	-3.700	<.001	.001	3	1
UCEC	eIF4G →	+0.308	+3.321	.011	.010	3	1
UCEC	Gab2 →	+0.396	+2.321	.004	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

MEK1 by ANKS4B expression — UCEC

Explore this box plot interactively →