ANKRD6

Across TCGA patient cohorts, ANKRD6 mutation is significantly associated with the RNA expression of many other genes, with 1,571 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKRD6-associated genes across cancer lineages are ERHP2, RNA5SP86, and CYP27B1. Each is linked with ANKRD6 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANKRD6-to-partner and partner-to-ANKRD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERHP2 grouped by ANKRD6-low versus ANKRD6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKRD6→partner) and Y-score (partner→ANKRD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ERHP2 →	+0.075	+4.897	<.001	.002	3	3
BRCA	RNA5SP86 →	+0.265	+5.548	<.001	.001	3	3
UCEC	CYP27B1 →	+0.396	+3.483	.001	<.001	3	2
UCEC	EEF2KMT →	+0.385	+2.136	.001	<.001	3	2
UCEC	PPP6C →	+0.370	+2.362	.001	<.001	3	2
UCEC	NARS1 →	+0.346	+1.836	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,571 associations by consensus.

ERHP2 by ANKRD6 expression — SKCM

Explore this box plot interactively →