ANKRD6

Across TCGA pan-cancer cohorts, ANKRD6 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ANKRD6 data layer compared with 9 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher ANKRD6 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ANKRD6 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

STAD, KIRC, and KICH are the cancer types where ANKRD6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.338	0.501	<.001	102	view →
KIRC	OS	Median	All	0.709	0.558	<.001	87	view →
KICH	OS	Median	All	0.731	1.000	<.001	65	view →
KIRP	DFS	Tertile	All	0.613	0.777	.002	58	view →
SKCM	OS	Tertile	II,III,IV	0.558	0.135	.001	46	view →
LUAD	OS	Median	All	0.858	0.712	.002	42	view →
COAD	DFS	Median	All	0.314	0.603	<.001	42	view →
BLCA	OS	Quartile	All	0.368	0.746	.007	38	view →
LIHC	DFS	Tertile	All	0.455	0.609	.002	31	view →
UCS	OS	Median	II,III,IV	0.587	0.232	.004	24	view →
LUSC	DFS	Quartile	III,IV	0.358	0.700	.005	20	view →
ESCA	OS	Tertile	All	1.000	0.577	.024	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ANKRD6–STAD (OS)

Open the STAD breakdown →