ANKRD49

Across TCGA pan-cancer cohorts, ANKRD49 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ANKRD49 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ANKRD49 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ANKRD49 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and UCEC are the cancer types where ANKRD49 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.901	0.536	.001	41	view →
PDAC	DFS	Quartile	All	0.541	0.290	.021	8	view →
UCEC	DFS	Tertile	All	0.942	0.752	.018	4	view →
LSCC	OS	Tertile	All	0.893	0.688	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ANKRD49–CCRCC (DFS)

Open the CCRCC breakdown →