ANKRD49

Across TCGA pan-cancer cohorts, ANKRD49 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ANKRD49’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ANKRD49 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ANKRD49 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where ANKRD49 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANKRD49 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.794	<.001	12	view →
LIHC	Female	II,III,IV	+0.904	<.001	9	view →
THCA	Male	III,IV	−0.727	<.001	8	view →
BLCA	All	All	+0.429	.007	6	view →
CHOL	Female	All	+1.983	<.001	5	view →
LUAD	All	All	+0.369	<.001	5	view →
STAD	All	II,III,IV	+0.635	.004	4	view →
LUSC	Male	All	+0.461	<.001	4	view →
COAD	All	All	+0.367	.002	4	view →
KICH	All	All	−0.464	.006	3	view →
KIRC	All	All	+0.260	<.001	3	view →
ESCA	All	All	+0.588	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ANKRD49–HNSC

Open the HNSC breakdown →