ANKRD49

Across TCGA patient cohorts, ANKRD49 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKRD49-associated genes across cancer lineages are FoxM1, Ku80, and Notch1. Each is linked with ANKRD49 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKRD49-to-partner and partner-to-ANKRD49 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by ANKRD49-low versus ANKRD49-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKRD49→partner) and Y-score (partner→ANKRD49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.348	+3.321	.010	.010	3	2
UCEC	Ku80 →	+0.296	+2.183	.016	.035	3	1
UCEC	Notch1 →	+0.262	+2.820	<.001	.035	3	1
UCEC	STAT3_pY705 →	-0.398	-3.321	.003	.010	3	1
UCEC	B-Raf →	+0.378	+3.321	.045	.010	3	1
UCEC	Cyclin-E2 →	+0.173	+3.009	.049	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

FoxM1 by ANKRD49 expression — UCEC

Explore this box plot interactively →