ANKRD34C

Across TCGA patient cohorts, ANKRD34C mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKRD34C-associated genes across cancer lineages are eIF4E, Notch1, and PDCD4. Each is linked with ANKRD34C in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKRD34C-to-partner and partner-to-ANKRD34C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ANKRD34C-low versus ANKRD34C-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKRD34C→partner) and Y-score (partner→ANKRD34C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.204	+2.182	.006	.033	3	2
UCEC	Notch1 →	+0.100	+1.424	.017	.027	3	2
UCEC	PDCD4 →	-0.367	-1.184	.008	.022	3	2
UCEC	Annexin-1 →	+0.516	+2.087	.001	.004	3	2
COAD	ATM →	-0.658	-3.459	<.001	.004	3	2
COAD	Caspase-7-cleavedD198 →	+1.026	+1.882	.001	.031	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

eIF4E by ANKRD34C expression — COAD

Explore this box plot interactively →