ANKRD34C

Across TCGA pan-cancer cohorts, ANKRD34C RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ANKRD34C data layer compared with 4 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher ANKRD34C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ANKRD34C expression acts as an unfavorable survival marker, although some lineages such as ESCA and SARC show a favorable association.

KICH, ESCA, and KIRP are the cancer types where ANKRD34C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	II,III,IV	0.495	0.952	.002	80	view →
ESCA	DFS	Quartile	III,IV	0.704	0.255	.001	51	view →
KIRP	OS	Tertile	All	0.568	0.817	<.001	41	view →
THYM	OS	Tertile	All	0.709	0.928	.020	39	view →
READ	OS	Tertile	II,III,IV	0.628	0.977	<.001	33	view →
SARC	DFS	Tertile	All	0.641	0.447	.001	28	view →
OV	DFS	Tertile	IV	0.515	0.233	.002	20	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
LGG	DFS	Tertile	All	0.886	0.765	.002	16	view →
DLBC	OS	Quartile	III,IV	0.260	0.899	.035	11	view →
CHOL	DFS	Tertile	II,III,IV	0.791	0.194	.031	6	view →
SKCM	DFS	Tertile	IV	0.943	0.214	.022	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ANKRD34C–KICH (DFS)

Open the KICH breakdown →