ANKRD18A

Across TCGA pan-cancer cohorts, ANKRD18A RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated ANKRD18A data layer compared with 6 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ANKRD18A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ANKRD18A expression acts as an unfavorable survival marker, although some lineages such as BRCA and SCLC show a favorable association.

ACC, BRCA, and HNSC are the cancer types where ANKRD18A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.375	0.779	<.001	86	view →
BRCA	DFS	Tertile	All	0.978	0.937	<.001	62	view →
HNSC	DFS	Quartile	All	0.198	0.475	<.001	59	view →
COAD	OS	Quartile	All	0.715	0.878	.002	41	view →
UVM	OS	Tertile	All	0.414	0.703	.002	18	view →
PRAD	OS	Quartile	All	0.724	0.940	.002	12	view →
SCLC	OS	Quartile	All	0.563	0.277	.025	10	view →
PAAD	OS	Quartile	All	0.419	0.579	.024	10	view →
LUSC	OS	Median	III,IV	0.451	0.667	.011	8	view →
READ	OS	Tertile	IV	0.966	0.574	.016	8	view →
THCA	OS	Quartile	All	0.951	0.993	.021	7	view →
PCPG	DFS	Quartile	All	0.732	0.927	.019	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

ANKRD18A–ACC (DFS)

Open the ACC breakdown →