ANKRD18A

Across TCGA pan-cancer cohorts, ANKRD18A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ANKRD18A’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ANKRD18A RNA is repressed in tumor relative to normal tissue. In most cancer types ANKRD18A is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and COAD are the cancer types where ANKRD18A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANKRD18A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.081	<.001	11	view →
KIRC	Male	III,IV	−0.318	<.001	11	view →
COAD	Male	All	+0.632	<.001	10	view →
KIRP	Male	II,III,IV	+0.533	.005	8	view →
LUAD	All	All	+0.466	<.001	7	view →
CHOL	All	All	+1.146	<.001	5	view →
LUSC	All	All	+0.510	<.001	5	view →
READ	All	III,IV	+0.790	.009	4	view →
STAD	Male	All	+0.755	.004	4	view →
ESCA	All	II,III,IV	+0.464	.022	2	view →
PRAD	All	All	+0.286	<.001	2	view →
HNSC	Male	II,III,IV	+0.209	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ANKRD18A–THCA

Open the THCA breakdown →