ANKRD11

Across TCGA patient cohorts, ANKRD11 mutation is significantly associated with the total protein of many other genes, with 100 significant associations in total. COAD shows the largest number of these associations.

The most reproducible ANKRD11-associated genes across cancer lineages are FASN, Cyclin-B1, and ERK2. Each is linked with ANKRD11 in more than 3 cancer types. Because this analysis shows association rather than direction, both ANKRD11-to-partner and partner-to-ANKRD11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by ANKRD11-low versus ANKRD11-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKRD11→partner) and Y-score (partner→ANKRD11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FASN →	+0.432	+3.700	<.001	.001	3	4
UCEC	Cyclin-B1 →	+0.537	+3.392	<.001	<.001	3	4
UCEC	ERK2 →	+0.160	+1.536	.001	.001	3	4
COAD	Bad_pS112 →	-0.195	-2.567	.001	.009	3	4
STAD	eEF2 →	+0.356	+2.000	.003	.030	2	4
STAD	N-Ras →	-0.119	-2.700	.012	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

FASN by ANKRD11 expression — COAD

Explore this box plot interactively →