ANKRD11

Across TCGA pan-cancer cohorts, ANKRD11 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ANKRD11’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where ANKRD11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ANKRD11 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

KIRP, HNSC, and THCA are the cancer types where ANKRD11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANKRD11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+0.788	<.001	10	view →
HNSC	All	All	+0.573	<.001	10	view →
THCA	All	II,III,IV	−0.577	<.001	9	view →
LIHC	Female	II,III,IV	+0.983	<.001	7	view →
BRCA	Female	All	−0.385	<.001	6	view →
KIRC	All	All	+0.285	<.001	6	view →
CHOL	Male	All	+2.133	<.001	5	view →
STAD	All	II,III,IV	+0.751	.004	5	view →
UCEC	All	All	−0.433	.033	2	view →
COAD	All	All	+0.235	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ANKRD11–KIRP

Open the KIRP breakdown →