ANKRD1

Across TCGA patient cohorts, ANKRD1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKRD1-associated genes across cancer lineages are ATM, 4E-BP1_pT37_T46, and MEK1. Each is linked with ANKRD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKRD1-to-partner and partner-to-ANKRD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ANKRD1-low versus ANKRD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKRD1→partner) and Y-score (partner→ANKRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.617	-1.700	.001	.044	3	2
UCEC	4E-BP1_pT37_T46 →	-0.400	-3.156	.012	.018	3	2
UCEC	MEK1 →	+0.375	+2.222	.015	.011	3	1
UCEC	mTOR_pS2448 →	-0.131	-2.302	.039	.034	3	1
UCEC	Notch1 →	+0.146	+1.700	.014	.044	3	1
UCEC	p27_pT198 →	+0.092	+1.700	.042	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ATM by ANKRD1 expression — UCEC

Explore this box plot interactively →