ANKRD1

Across TCGA pan-cancer cohorts, ANKRD1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ANKRD1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where ANKRD1 RNA is repressed in tumor relative to normal tissue. In most cancer types ANKRD1 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and STAD are the cancer types where ANKRD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANKRD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	−6.402	<.001	9	view →
LUAD	Female	III,IV	−4.670	<.001	9	view →
STAD	Female	All	+0.111	.016	9	view →
KICH	All	II,III,IV	−1.464	<.001	7	view →
UCEC	All	All	+1.086	<.001	6	view →
COAD	All	II,III,IV	+0.103	.003	4	view →
CHOL	All	All	+3.269	.001	3	view →
LIHC	All	II,III,IV	+0.982	.015	3	view →
PRAD	All	All	−0.612	.037	2	view →
HNSC	Male	IV	−2.562	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ANKRD1–LUSC

Open the LUSC breakdown →