ANKHD1-EIF4EBP3

Across TCGA pan-cancer cohorts, ANKHD1-EIF4EBP3 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ANKHD1-EIF4EBP3 data layer compared with 11 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ANKHD1-EIF4EBP3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ANKHD1-EIF4EBP3 expression acts as an unfavorable survival marker, although some lineages such as MESO and PAAD show a favorable association.

UVM, MESO, and LIHC are the cancer types where ANKHD1-EIF4EBP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.449	0.889	.001	81	view →
MESO	OS	Median	All	0.510	0.271	<.001	81	view →
LIHC	OS	Median	All	0.446	0.661	<.001	49	view →
PAAD	DFS	Median	All	0.438	0.263	.001	40	view →
DLBC	DFS	Median	II,III,IV	0.912	0.501	.005	30	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	23	view →
LGG	DFS	Tertile	All	0.777	0.904	<.001	22	view →
THCA	DFS	Quartile	All	0.913	0.758	.005	18	view →
UCEC	OS	Tertile	All	0.767	0.569	.010	18	view →
BRCA	OS	Tertile	III,IV	0.959	0.856	.009	9	view →
UCS	DFS	Quartile	III,IV	0.102	0.351	.042	6	view →
BLCA	OS	Median	All	0.550	0.359	.016	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ANKHD1-EIF4EBP3–UVM (OS)

Open the UVM breakdown →