ANKHD1-EIF4EBP3

Across TCGA pan-cancer cohorts, ANKHD1-EIF4EBP3 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of ANKHD1-EIF4EBP3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ANKHD1-EIF4EBP3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ANKHD1-EIF4EBP3 is over-expressed in tumor, although a few such as LUSC and COAD show the opposite, repressed pattern.

KIRC, LUSC, and LIHC are the cancer types where ANKHD1-EIF4EBP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANKHD1-EIF4EBP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.348	<.001	11	view →
LUSC	Female	All	−0.490	<.001	8	view →
LIHC	Female	II,III,IV	+0.408	<.001	8	view →
COAD	All	All	−0.174	.001	6	view →
CHOL	All	All	+0.678	<.001	3	view →
PRAD	All	All	+0.329	<.001	2	view →
THCA	All	All	+0.119	.010	2	view →
KIRP	All	All	+0.223	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

ANKHD1-EIF4EBP3–KIRC

Open the KIRC breakdown →