ANKH

Across TCGA patient cohorts, ANKH protein abundance is significantly associated with the RNA expression of many other genes, with 1,362 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ANKH-associated genes across cancer lineages are ADGRB3, ST6GAL2-IT1, and RNU6-1231P. Each is linked with ANKH in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKH-to-partner and partner-to-ANKH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ANKH versus ADGRB3 in GBM, with a Pearson correlation of -0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKH→partner) and Y-score (partner→ANKH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ADGRB3 →	-1.187	-0.857	<.001	<.001	3	2
OV	ST6GAL2-IT1 →	+0.602	+0.364	.006	.009	3	2
OV	RNU6-1231P →	+0.802	+0.395	.003	.006	3	2
PDAC	CD9 →	+0.472	+0.447	.009	.006	3	1
PDAC	RASL12 →	-0.430	-0.397	.006	.007	3	1
PDAC	KIR3DX1 →	+0.035	+0.564	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,362 associations by consensus.

ANKH vs ADGRB3 — GBM

Explore this scatter interactively →