ANKH

Across TCGA pan-cancer cohorts, ANKH RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated ANKH data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ANKH RNA is associated with better overall survival. In most high-consensus cancer types, elevated ANKH expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

KIRC, MESO, and HNSC are the cancer types where ANKH RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.865	0.749	<.001	75	view →
MESO	OS	Median	II,III,IV	0.279	0.503	<.001	63	view →
HNSC	DFS	Tertile	IV	0.745	0.533	.001	43	view →
KIRP	DFS	Median	II,III,IV	0.188	0.656	.002	34	view →
ACC	DFS	Tertile	II,III,IV	0.168	0.575	.007	32	view →
THCA	DFS	Median	IV	1.000	0.501	.001	31	view →
SCLC	OS	Median	All	0.518	0.204	.005	28	view →
STAD	OS	Tertile	All	0.421	0.662	.024	19	view →
UVM	OS	Median	III,IV	0.281	1.000	.003	17	view →
PAAD	OS	Median	All	0.688	0.481	.006	16	view →
GBM	OS	Quartile	All	0.317	0.461	.008	14	view →
COAD	OS	Quartile	IV	0.823	0.443	.025	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

ANKH–KIRC (OS)

Open the KIRC breakdown →