ANKH

Across TCGA patient cohorts, ANKH mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKH-associated genes across cancer lineages are Bak, Chk2_pT68, and 14-3-3_beta. Each is linked with ANKH in more than 2 cancer types. Because this analysis shows association rather than direction, both ANKH-to-partner and partner-to-ANKH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bak grouped by ANKH-low versus ANKH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKH→partner) and Y-score (partner→ANKH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bak →	+0.249	+1.700	.009	.042	3	2
UCEC	Chk2_pT68 →	-0.181	-3.690	.011	.001	2	3
UCEC	14-3-3_beta →	-0.083	-3.295	.031	.009	3	1
UCEC	eEF2 →	+0.376	+3.459	.006	.005	3	1
UCEC	EGFR_pY1068 →	-0.269	-1.678	.005	.023	3	1
UCEC	eIF4E →	+0.232	+3.807	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Bak by ANKH expression — UCEC

Explore this box plot interactively →