ANKEF1

Across TCGA cell cohorts, ANKEF1 mutation is significantly associated with the RNA expression of many other genes, with 178 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANKEF1-associated genes across cancer lineages are CEACAM3, KRTAP2-4, and ASB10. Each is linked with ANKEF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANKEF1-to-partner and partner-to-ANKEF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEACAM3 grouped by ANKEF1-low versus ANKEF1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKEF1→partner) and Y-score (partner→ANKEF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CEACAM3 →	+0.053	+4.807	<.001	.006	3	1
BLOOD_Myeloma	KRTAP2-4 →	+0.049	+4.807	<.001	.006	3	1
LUNG_NSCLC_LUAD	ASB10 →	+0.014	+5.189	<.001	<.001	3	1
LUNG_NSCLC_LUAD	PRR23A →	+0.037	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	KRTAP4-7 →	+0.172	+4.212	.003	.007	3	1
LUNG_NSCLC_LUAD	OR4E1 →	+0.010	+5.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 178 associations by consensus.

CEACAM3 by ANKEF1 expression — BLOOD_Myeloma

Explore this box plot interactively →