ANK3

Across TCGA patient cohorts, ANK3 mutation is significantly associated with the RNA expression of many other genes, with 9,850 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANK3-associated genes across cancer lineages are NCAPH, KIF2C, and GHITM. Each is linked with ANK3 in more than 6 cancer types. Because this analysis shows association rather than direction, both ANK3-to-partner and partner-to-ANK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCAPH grouped by ANK3-low versus ANK3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANK3→partner) and Y-score (partner→ANK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	NCAPH →	+0.535	+2.153	.008	<.001	3	7
STAD	KIF2C →	+0.600	+3.819	.002	<.001	3	6
STAD	GHITM →	+0.520	+2.955	<.001	<.001	3	6
CESC	BNIP3 →	+0.894	+3.184	.008	.009	3	6
STAD	ITPK1 →	+0.553	+2.459	<.001	<.001	3	6
STAD	ATP5F1B →	+0.579	+2.938	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,850 associations by consensus.

NCAPH by ANK3 expression — STAD

Explore this box plot interactively →