ANK3-DT

Across TCGA pan-cancer cohorts, ANK3-DT RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ANK3-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ANK3-DT RNA is repressed in tumor relative to normal tissue. In most cancer types ANK3-DT is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where ANK3-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANK3-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.512	<.001	12	view →
KIRP	All	All	−1.076	<.001	9	view →
KICH	All	All	−1.322	<.001	6	view →
THCA	Male	IV	−1.076	<.001	6	view →
BLCA	All	All	+0.586	.003	6	view →
BRCA	All	All	+0.280	<.001	4	view →
COAD	Female	II,III,IV	+0.159	.016	4	view →
CHOL	All	All	+0.710	<.001	3	view →
LUAD	All	All	−0.333	.007	3	view →
LUSC	All	II,III,IV	−0.382	.038	2	view →
LIHC	All	II,III,IV	+0.075	.026	2	view →
HNSC	Female	III,IV	−0.543	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ANK3-DT–KIRC

Open the KIRC breakdown →