Across TCGA pan-cancer cohorts, ANK2-AS1 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of ANK2-AS1’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where ANK2-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ANK2-AS1 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.
COAD are the cancer types where ANK2-AS1 tumor–normal differential expression is most reproducible.