ANGPTL7

Across TCGA patient cohorts, ANGPTL7 mutation is significantly associated with the RNA expression of many other genes, with 705 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANGPTL7-associated genes across cancer lineages are RNU6-1252P, RNU1-49P, and RNA5SP232. Each is linked with ANGPTL7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGPTL7-to-partner and partner-to-ANGPTL7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1252P grouped by ANGPTL7-low versus ANGPTL7-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL7→partner) and Y-score (partner→ANGPTL7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-1252P →	+0.657	+7.731	<.001	.009	3	2
BRCA	RNU1-49P →	+0.289	+8.471	<.001	.005	3	2
BRCA	RNA5SP232 →	+0.600	+8.055	<.001	.007	3	2
BRCA	RNU6-391P →	+0.657	+7.731	<.001	.009	3	2
COAD	RPS12P15 →	+0.148	+4.693	<.001	.007	3	2
UCEC	CD24P1 →	+0.224	+2.092	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 705 associations by consensus.

RNU6-1252P by ANGPTL7 expression — BRCA

Explore this box plot interactively →