ANGPTL6

Across TCGA patient cohorts, ANGPTL6 mutation is significantly associated with the RNA expression of many other genes, with 123 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANGPTL6-associated genes across cancer lineages are RNA5SP319, RN7SKP264, and MTND1P6. Each is linked with ANGPTL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGPTL6-to-partner and partner-to-ANGPTL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP319 grouped by ANGPTL6-low versus ANGPTL6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL6→partner) and Y-score (partner→ANGPTL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP319 →	+0.473	+2.798	.008	.008	3	2
UCEC	RN7SKP264 →	+0.386	+3.351	<.001	.003	3	2
SKCM	MTND1P6 →	+0.051	+4.979	<.001	.009	3	2
SKCM	RN7SL237P →	+0.162	+5.436	<.001	.005	3	2
SKCM	MIR3945 →	+0.397	+4.979	<.001	.009	3	2
COAD	MIR6075 →	+0.813	+3.717	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 123 associations by consensus.

RNA5SP319 by ANGPTL6 expression — UCEC

Explore this box plot interactively →