ANGPTL2

Across TCGA pan-cancer cohorts, ANGPTL2 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ANGPTL2 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ANGPTL2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ANGPTL2 expression acts as an unfavorable survival marker.

LUAD, PDAC, and LSCC are the cancer types where ANGPTL2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.742	0.927	.004	32	view →
PDAC	DFS	Median	All	0.723	0.867	.006	18	view →
LSCC	DFS	Tertile	II,III,IV	0.573	0.948	.006	16	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ANGPTL2–LUAD (OS)

Open the LUAD breakdown →