ANGPTL2

Across TCGA pan-cancer cohorts, ANGPTL2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ANGPTL2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ANGPTL2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ANGPTL2 is over-expressed in tumor, although a few such as BLCA and KICH show the opposite, repressed pattern.

KIRC, BLCA, and KICH are the cancer types where ANGPTL2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ANGPTL2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+1.646	<.001	12	view →
BLCA	Male	All	−1.638	.001	8	view →
KICH	Female	All	−1.852	<.001	6	view →
LUAD	Male	III,IV	+1.736	.001	6	view →
BRCA	All	All	−1.500	<.001	6	view →
HNSC	Female	All	+1.073	.021	4	view →
ESCA	Male	All	+2.445	.014	2	view →
UCEC	All	All	−1.347	.002	2	view →
PRAD	All	All	−0.584	.005	2	view →
THCA	All	All	+0.305	.029	2	view →
READ	Female	All	−1.584	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ANGPTL2–KIRC

Open the KIRC breakdown →