ANGPTL2

Across TCGA patient cohorts, ANGPTL2 mutation is significantly associated with the RNA expression of many other genes, with 1,288 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANGPTL2-associated genes across cancer lineages are POLR2J4, DUSP15, and SLC7A11. Each is linked with ANGPTL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGPTL2-to-partner and partner-to-ANGPTL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLR2J4 grouped by ANGPTL2-low versus ANGPTL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL2→partner) and Y-score (partner→ANGPTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POLR2J4 →	-0.342	-2.066	.002	.005	3	2
UCEC	DUSP15 →	-0.564	-1.756	.008	.002	3	2
UCEC	SLC7A11 →	+0.602	+2.233	.007	.005	3	2
UCEC	CXCL13 →	+1.418	+3.000	<.001	<.001	3	2
UCEC	PKN3 →	+0.552	+1.534	<.001	.005	3	2
UCEC	RBM47 →	+0.547	+3.828	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,288 associations by consensus.

POLR2J4 by ANGPTL2 expression — UCEC

Explore this box plot interactively →