ANGPTL2

Across TCGA cell cohorts, ANGPTL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,640 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ANGPTL2-associated GO terms across cancer lineages are Regulation of DNA-templated transcription initiation, Malonyl-CoA catabolic process, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with ANGPTL2 in more than 7 cancer types. Because this analysis shows association rather than direction, both ANGPTL2-to-partner and partner-to-ANGPTL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA-templated transcription initiation grouped by ANGPTL2-low versus ANGPTL2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL2→partner) and Y-score (partner→ANGPTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of DNA-templated transcription initiation →	+0.052	+1.727	<.001	.006	3	7
SOFT_TISSUE	Malonyl-CoA catabolic process →	-0.789	-2.108	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.100	+1.182	<.001	<.001	3	7
SOFT_TISSUE	Pyridine-containing compound catabolic process →	+0.078	+1.923	.002	.008	3	7
SOFT_TISSUE	Coenzyme A catabolic process →	-0.900	-2.998	<.001	<.001	3	6
SOFT_TISSUE	Formation of primary germ layer →	+0.128	+2.207	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,640 associations by consensus.

Regulation of DNA-templated transcription initiation by ANGPTL2 expression — SOFT_TISSUE

Explore this box plot interactively →