ANGPTL2

Across TCGA cell cohorts, ANGPTL2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ANGPTL2-associated genes across cancer lineages are OR5A2, OR1L3, and MDFIC2. Each is linked with ANGPTL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGPTL2-to-partner and partner-to-ANGPTL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5A2 grouped by ANGPTL2-low versus ANGPTL2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL2→partner) and Y-score (partner→ANGPTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR5A2 →	+0.006	+6.266	<.001	<.001	3	1
SKIN	OR1L3 →	+0.019	+5.415	<.001	.004	3	1
SKIN	MDFIC2 →	+0.155	+4.977	<.001	.007	3	1
LARGE_INTESTINE	FAM205A →	+0.017	+3.029	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR5A2 by ANGPTL2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →