ANGPTL1

Across TCGA cell cohorts, ANGPTL1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ANGPTL1-associated genes across cancer lineages are CFHR4, ARHGAP36, and IFNL2. Each is linked with ANGPTL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGPTL1-to-partner and partner-to-ANGPTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR4 grouped by ANGPTL1-low versus ANGPTL1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPTL1→partner) and Y-score (partner→ANGPTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CFHR4 →	+0.097	+4.339	.004	.002	3	1
BLOOD_Leukemia	ARHGAP36 →	+0.018	+3.944	<.001	.006	3	1
BLOOD_Leukemia	IFNL2 →	+0.077	+4.060	<.001	.003	3	1
BLOOD_Leukemia	OR4F5 →	+0.064	+3.874	<.001	.005	3	1
BLOOD_Leukemia	TSSK1B →	+0.009	+3.874	<.001	.005	3	1
BLOOD_Leukemia	OR4E2 →	+1.170	+3.874	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

CFHR4 by ANGPTL1 expression — BLOOD_Leukemia

Explore this box plot interactively →