ANGPT4

Across TCGA patient cohorts, ANGPT4 mutation is significantly associated with the RNA expression of many other genes, with 3,164 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANGPT4-associated genes across cancer lineages are PSMD9, C12orf43, and RPL23AP82. Each is linked with ANGPT4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ANGPT4-to-partner and partner-to-ANGPT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMD9 grouped by ANGPT4-low versus ANGPT4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPT4→partner) and Y-score (partner→ANGPT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PSMD9 →	+0.542	+3.223	<.001	.009	3	4
UCEC	C12orf43 →	+0.272	+3.881	.001	<.001	3	4
UCEC	RPL23AP82 →	+0.465	+3.928	<.001	<.001	3	3
UCEC	CDCA2 →	+0.932	+2.584	<.001	<.001	3	3
UCEC	ERCC6L →	+0.649	+3.711	<.001	<.001	3	3
UCEC	H2AX →	+0.524	+2.263	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,164 associations by consensus.

PSMD9 by ANGPT4 expression — COAD

Explore this box plot interactively →