ANGPT4

Across TCGA patient cohorts, ANGPT4 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANGPT4-associated genes across cancer lineages are ASNS, c-Jun_pS73, and STAT3_pY705. Each is linked with ANGPT4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANGPT4-to-partner and partner-to-ANGPT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ANGPT4-low versus ANGPT4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPT4→partner) and Y-score (partner→ANGPT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.305	+1.362	.016	.037	3	3
UCEC	c-Jun_pS73 →	-0.163	-2.392	.003	<.001	3	3
UCEC	STAT3_pY705 →	-0.391	-1.755	<.001	.013	3	2
COAD	PCNA →	+0.306	+2.815	.024	.036	3	2
COAD	Caspase-7-cleavedD198 →	+1.636	+2.815	<.001	.036	3	2
UCEC	14-3-3_beta →	-0.089	-1.649	.012	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ASNS by ANGPT4 expression — UCEC

Explore this box plot interactively →