ANGPT4

Across TCGA cell cohorts, ANGPT4 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ANGPT4-associated genes across cancer lineages are KRTAP19-4, HELT, and PRB4. Each is linked with ANGPT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGPT4-to-partner and partner-to-ANGPT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP19-4 grouped by ANGPT4-low versus ANGPT4-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGPT4→partner) and Y-score (partner→ANGPT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	KRTAP19-4 →	+0.139	+4.754	<.001	.005	3	1
CNS	HELT →	+0.030	+4.321	<.001	.009	3	1
CNS	PRB4 →	+0.214	+4.832	<.001	.002	3	1
LARGE_INTESTINE	SH3GL2 →	+1.643	+3.252	<.001	.009	3	1
LARGE_INTESTINE	CR2 →	+1.167	+3.363	<.001	.004	3	1
LARGE_INTESTINE	IDI2 →	+0.023	+3.257	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

KRTAP19-4 by ANGPT4 expression — CNS

Explore this box plot interactively →