ANGEL2

Across TCGA patient cohorts, ANGEL2 mutation is significantly associated with the RNA expression of many other genes, with 889 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANGEL2-associated genes across cancer lineages are OR11J5P, MIR541, and LINC00428. Each is linked with ANGEL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ANGEL2-to-partner and partner-to-ANGEL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11J5P grouped by ANGEL2-low versus ANGEL2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANGEL2→partner) and Y-score (partner→ANGEL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	OR11J5P →	+0.068	+5.578	<.001	.002	3	2
LUAD	MIR541 →	+0.416	+4.631	<.001	.008	3	2
COAD	LINC00428 →	+0.264	+7.734	<.001	<.001	3	2
UCEC	RNA5SP90 →	+0.189	+2.379	<.001	.008	3	2
UCEC	HMGB1P26 →	+0.147	+1.551	.004	.007	3	2
UCEC	COPS8P1 →	+0.072	+1.801	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 889 associations by consensus.

OR11J5P by ANGEL2 expression — LUSC

Explore this box plot interactively →