ANAPC4

Across TCGA patient cohorts, ANAPC4 protein abundance is significantly associated with the RNA expression of many other genes, with 8,635 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANAPC4-associated genes across cancer lineages are DIAPH3, FANCD2, and POC1A. Each is linked with ANAPC4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ANAPC4-to-partner and partner-to-ANAPC4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ANAPC4 versus DIAPH3 in LSCC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANAPC4→partner) and Y-score (partner→ANAPC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DIAPH3 →	+0.681	+0.118	<.001	<.001	3	4
LSCC	FANCD2 →	+0.690	+0.181	<.001	<.001	3	4
GBM	POC1A →	+0.757	+0.122	<.001	.003	3	4
GBM	RRM2 →	+0.895	+0.121	.002	.008	3	4
LUAD	UBE2C →	+1.085	+0.109	.003	.003	3	4
LUAD	KIF18B →	+0.770	+0.120	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,635 associations by consensus.

ANAPC4 vs DIAPH3 — LSCC

Explore this scatter interactively →